In vitro fertilization (IVF) is a complex series of procedures used to treat fertility or genetic problems and assist with the conception of a child. Ivf in Iran is done.
During IVF, mature eggs are collected (retrieved) from your ovaries and fertilized by sperm in a lab. Then the fertilized egg (embryo) or eggs are implanted in your uterus. One cycle of IVF takes about two weeks.
IVF is the most effective form of assisted reproductive technology. The procedure can be done using your own eggs and your partner’s sperm. Or IVF may involve eggs, sperm or embryos from a known or anonymous donor. In some cases, a gestational carrier — a woman who has an embryo implanted in her uterus might be used. Ivf in Iran is done.
Your chances of having a healthy baby using IVF depend on many factors, such as your age and the cause of infertility. In addition, IVF can be time-consuming, expensive and invasive. If more than one embryo is implanted in your uterus, IVF can result in a pregnancy with more than one fetus (multiple pregnancy).
Why it’s done
If IVF is performed to treat infertility, you and your partner might be able to try less invasive treatment options before attempting IVF, including fertility drugs to increase production of eggs or intrauterine insemination, a procedure in which sperm are placed directly in your uterus near the time of ovulation. Ivf in Iran is done.
Sometimes, IVF is offered as a primary treatment for infertility in women over age 40. IVF can also be done if you have certain health conditions. For example, IVF may be an option if you or your partner has:
- Fallopian tube damage or blockage. Or blockage makes it difficult for an egg to be fertilized or for an embryo to travel to the uterus.
- Ovulation disorders. If ovulation is infrequent or absent, fewer eggs are available for fertilization.
- Premature ovarian failure. Is the loss of normal ovarian function before age 40. If your ovaries fail, they don’t produce normal amounts of the hormone estrogen or have eggs to release regularly. Ivf in Iran is done.
- Endometriosis occurs when the uterine tissue implants and grows outside of the uterus often affecting the function of the ovaries, uterus and fallopian tubes.
- Uterine fibroids. Fibroids are benign tumors in the wall of the uterus and are common in women in their 30s and 40s. Fibroids can interfere with implantation of the fertilized egg.
- Previous tubal sterilization or removal. If you’ve had tubal ligation — a type of sterilization in which your fallopian tubes are cut or blocked to permanently prevent pregnancy — and want to conceive, IVF may be an alternative to tubal ligation reversal.
- Impaired sperm production or function. Below-average sperm concentration, weak movement of sperm (poor mobility), or abnormalities in sperm size and shape can make it difficult for sperm to fertilize an egg. If semen abnormalities are found, your partner might need to see a specialist to determine if there are correctable problems or underlying health concerns. Ivf in Iran is done.
- Unexplained infertility. Unexplained infertility means no cause of infertility has been found despite evaluation for common causes.
- A genetic disorder. If you or your partner is at risk of passing on a genetic disorder to your child, you may be candidates for preimplantation genetic diagnosis — a procedure that involves IVF. After the eggs are harvested and fertilized, they’re screened for certain genetic problems, although not all genetic problems can be found. Embryos that don’t contain identified problems can be transferred to the uterus.
- Fertility preservation for cancer or other health conditions. If you’re about to start cancer treatment — such as radiation or chemotherapy — that could harm your fertility, IVF for fertility preservation may be an option. Women can have eggs harvested from their ovaries and frozen in an unfertilized state for later use. Or the eggs can be fertilized and frozen as embryos for future use. Ivf in Iran is done.
Women who don’t have a functional uterus or for whom pregnancy poses a serious health risk might choose IVF using another person to carry the pregnancy (gestational carrier). In this case, the woman’s eggs are fertilized with sperm, but the resulting embryos are placed in the gestational carrier’s uterus.
IVF in Iran
Health centers in the capital city Tehran, as well as Esfahan, Shiraz, and Yazd have a long history in infertility treatment and research. These centers are well-equipped and ready to offer their services to needy patients. Ivf in Iran is done.
Services are including, gender selection, stem cell biology and technology, reproductive biomedicine, endocrinology & female fertility, embryology, reproductive genetics, epidemiology & reproductive health, reproductive imaging, etc.
IVF cost in Iran
Egg fertilization in the laboratory is costly. Costs are varied and depending on recommended medications, also depending on what treatment needs to be done. The price of each cilinic varies from one another. Ivf in Iran is done.
Main costs include pre-implantation diagnosis (PGD) costs and surgery and post-surgery cares. Some couples need an ovule or a donation that increases the cost of treatment. The cost of IVF in the UK is approximately around £5,000 per cycle of treatment or more. In some countries, the price will drastically increase. The cost of IVF in Iran is sometimes 1/3 (or less) compared with institutes in the region or western countries.
What happens during the IVF process?
During IVF, eggs are removed from the ovaries of a woman and fertilised in a laboratory with sperm provided by her partner or a donor. One or two embryos – fertilised eggs – are implanted into the woman’s uterus (womb). Ivf in Iran is done.
Here are the typical stages in an IVF cycle:
- The woman’s natural menstrual cycle is switched off with daily injections or a nasal spray.
- The woman has injections of fertility hormones to stimulate her ovaries so she produces several eggs, instead of just one.
- When the eggs mature, they are collected using a fine needle, guided by ultrasound, under light sedation.
- The eggs are fertilised in the laboratory with sperm provided by the woman’s partner or a donor. Ivf in Iran is done.
- Fertilised eggs (embryos) are grown in an incubator for a few days.
- One or two healthy embryos are transferred into the woman’s uterus using a thin tube inserted into the vagina and cervix.
- If an embryo successfully implants, the woman becomes pregnant. She will need to wait two weeks for a pregnancy test.
- Any remaining healthy embryos can be frozen and stored for later use if needed.
Women who have IVF often have more than one cycle. Ivf in Iran is done.
There are many variations to the IVF procedure. For example, sperm or eggs may be collected from a donor. In some cases, a surrogate may carry the pregnancy.
Chances of success with IVF
On average, every time a woman has a cycle of IVF, she has about a 1 in 5 chance of becoming pregnant. That chance is higher for women younger than 35 years old, and lower for older women, decreasing with age. Ivf in Iran is done.
In Australia, fewer than half the women treated with IVF have a baby. Some women need up to 5 cycles of treatment to be successful, while others never fall pregnant. Younger women are much more likely to have a baby through IVF than older women.
So overall, most women who use IVF do not go home with a baby. But some do.
In vitro fertilization (IVF) involves several steps — ovulation induction, egg retrieval, sperm retrieval, fertilization and embryo transfer. One cycle of IVF can take about two weeks, and more than one cycle may be required. Ivf in Iran is done.
If you’re using your own eggs during IVF, at the start of a cycle you’ll begin treatment with synthetic hormones to stimulate your ovaries to produce multiple eggs rather than the single egg that normally develops each month. Multiple eggs are needed because some eggs won’t fertilize or develop normally after fertilization.
You may need several different medications, such as: Ivf in Iran is done.
- Medications for ovarian stimulation. To stimulate your ovaries, you might receive an injectable medication containing a follicle-stimulating hormone (FSH), a luteinizing hormone (LH) or a combination of both. These medications stimulate more than one egg to develop at a time.
- Medications for oocyte maturation. When the follicles are ready for egg retrieval — generally after eight to 14 days you will take human chorionic gonadotropin (HCG) or other medications to help the eggs mature.
- Medications to prevent premature ovulation. These medications prevent your body from releasing the developing eggs too soon. Ivf in Iran is done.
- Medications to prepare the lining of your uterus. On the day of egg retrieval or at the time of embryo transfer, your doctor might recommend that you begin taking progesterone supplements to make the lining of your uterus more receptive to implantation. Ivf in Iran is done.
Your doctor will work with you to determine which medications to use and when to use them.
Typically, you’ll need one to two weeks of ovarian stimulation before your eggs are ready for retrieval. To determine when the eggs are ready for collection, your doctor will likely perform:
- Vaginal ultrasound, an imaging exam of your ovaries to monitor the development of follicles — fluid-filled ovarian sacs where eggs mature
- Blood tests, to measure your response to ovarian stimulation medications — estrogen levels typically increase as follicles develop and progesterone levels remain low until after ovulation
Sometimes IVF cycles need to be canceled before egg retrieval for one of these reasons:
- Inadequate number of follicles developing Ivf in Iran is done.
- Premature ovulation
- Too many follicles developing, creating a risk of ovarian hyperstimulation syndrome
- Other medical issues
Egg retrieval can be done in your doctor’s office or a clinic 34 to 36 hours after the final injection and before ovulation. Ivf in Iran is done.
- During egg retrieval, you’ll be sedated and given pain medication.
- Transvaginal ultrasound aspiration is the usual retrieval method. An ultrasound probe is inserted into your vagina to identify follicles. Then a thin needle is inserted into an ultrasound guide to go through the vagina and into the follicles to retrieve the eggs.
- If your ovaries aren’t accessible through transvaginal ultrasound, an abdominal surgery or laparoscopy — a procedure in which a tiny incision is made near your navel and a slender viewing instrument (laparoscope) is inserted — may be used to guide the needle. Ivf in Iran is done.
- The eggs are removed from the follicles through a needle connected to a suction device. Multiple eggs can be removed in about 20 minutes.
- After egg retrieval, you may experience cramping and feelings of fullness or pressure. Ivf in Iran is done.
- Mature eggs are placed in a nutritive liquid (culture medium) and incubated. Eggs that appear healthy and mature will be mixed with sperm to attempt to create embryos. However, not all eggs may be successfully fertilized.
If you’re using your partner’s sperm, he’ll provide a semen sample at your doctor’s office or a clinic through masturbation the morning of egg retrieval. Other methods, such as testicular aspiration — the use of a needle or surgical procedure to extract sperm directly from the testicle — are sometimes required. Donor sperm also can be used. Sperm are separated from the semen fluid in the lab.
Fertilization can be attempted using two common methods: Ivf in Iran is done.
- Insemination. During insemination, healthy sperm and mature eggs are mixed and incubated overnight.
- Intracytoplasmic sperm injection (ICSI). In ICSI, a single healthy sperm is injected directly into each mature egg. ICSI is often used when semen quality or number is a problem or if fertilization attempts during prior IVF cycles failed.
In certain situations, your doctor may recommend other procedures before embryo transfer. Ivf in Iran is done.
- Assisted hatching. About five to six days after fertilization, an embryo “hatches” from its surrounding membrane (zona pellucida), allowing it to implant into the lining of the uterus. If you’re an older woman, or if you have had multiple failed IVF attempts, your doctor might recommend assisted hatching — a technique in which a hole is made in the zona pellucida just before transfer to help the embryo hatch and implant. Ivf in Iran is done.
- Preimplantation genetic testing. Embryos are allowed to develop in the incubator until they reach a stage where a small sample can be removed and tested for specific genetic diseases or the correct number of chromosomes, typically after five to six days of development. Embryos that don’t contain affected genes or chromosomes can be transferred to your uterus. While preimplantation genetic testing can reduce the likelihood that a parent will pass on a genetic problem, it can’t eliminate the risk. Prenatal testing may still be recommended.
Embryo transfer is done at your doctor’s office or a clinic and usually takes place two to six days after egg retrieval. Ivf in Iran is done.
- You might be given a mild sedative. The procedure is usually painless, although you might experience mild cramping.
- The doctor or nurse will insert a long, thin, flexible tube called a catheter into your vagina, through your cervix and into your uterus.
- A syringe containing one or more embryos suspended in a small amount of fluid is attached to the end of the catheter. Ivf in Iran is done.
- Using the syringe, the doctor or nurse places the embryo or embryos into your uterus.
If successful, an embryo will implant in the lining of your uterus about six to 10 days after egg retrieval.
After the procedure
After the embryo transfer, you can resume your normal daily activities. However, your ovaries may still be enlarged. Consider avoiding vigorous activity, which could cause discomfort.
Typical side effects include: Ivf in Iran is done.
- Passing a small amount of clear or bloody fluid shortly after the procedure — due to the swabbing of the cervix before the embryo transfer
- Breast tenderness due to high estrogen levels
- Mild bloating
- Mild cramping
If you develop moderate or severe pain after the embryo transfer, contact your doctor. He or she will evaluate you for complications such as infection, twisting of an ovary (ovarian torsion) and severe ovarian hyperstimulation syndrome. Ivf in Iran is done.
Specific steps of an in vitro fertilization (IVF) cycle carry risks, including:
- Multiple births. IVF increases the risk of multiple births if more than one embryo is implanted in your uterus. A pregnancy with multiple fetuses carries a higher risk of early labor and low birth weight than pregnancy with a single fetus does. Ivf in Iran is done.
- Premature delivery and low birth weight. Research suggests that use of IVF slightly increases the risk that a baby will be born early or with a low birth weight.
- Ovarian hyperstimulation syndrome. Use of injectable fertility drugs, such as human chorionic gonadotropin (HCG), to induce ovulation can cause ovarian hyperstimulation syndrome, in which your ovaries become swollen and painful.
Signs and symptoms typically last a week and include mild abdominal pain, bloating, nausea, vomiting and diarrhea. If you become pregnant, however, your symptoms might last several weeks. Rarely, it’s possible to develop a more-severe form of ovarian hyperstimulation syndrome that can also cause rapid weight gain and shortness of breath. Ivf in Iran is done.
- Miscarriage. The rate of miscarriage for women who conceive using IVF with fresh embryos is similar to that of women who conceive naturally — about 15 to 25 percent — but the rate increases with maternal age. Use of frozen embryos during IVF, however, may slightly increase the risk of miscarriage.
- Egg-retrieval procedure complications. Use of an aspirating needle to collect eggs could possibly cause bleeding, infection or damage to the bowel, bladder or a blood vessel. Risks are also associated with general anesthesia, if used. Ivf in Iran is done.
- Ectopic pregnancy. About 2 to 5 percent of women who use IVF will have an ectopic pregnancy — when the fertilized egg implants outside the uterus, usually in a fallopian tube. The fertilized egg can’t survive outside the uterus, and there’s no way to continue the pregnancy.
- Birth defects. The age of the mother is the primary risk factor in the development of birth defects, no matter how the child is conceived. More research is needed to determine whether babies conceived using IVF might be at increased risk of certain birth defects. Some experts believe that the use of IVF does not increase the risk of having a baby with birth defects.
- Ovarian cancer. Although some early studies suggested there may be a link between certain medications used to stimulate egg growth and the development of a specific type of ovarian tumor, more recent studies do not support these findings. Ivf in Iran is done.
- Stress. Use of IVF can be financially, physically and emotionally draining. Support from counselors, family and friends can help you and your partner through the ups and downs of infertility treatment.
The Centers for Disease Control and Prevention and the Society for Assisted Reproductive Technology provide information online about U.S. clinics’ individual pregnancy and live birth rates. Before beginning a cycle of IVF using your own eggs and sperm, you and your partner will likely need various screenings, including: Ivf in Iran is done.
- Ovarian reserve testing. To determine the quantity and quality of your eggs, your doctor might test the concentration of follicle-stimulating hormone (FSH), estradiol (estrogen) and antimullerian hormone in your blood during the first few days of your menstrual cycle. Test results, often used together with an ultrasound of your ovaries, can help predict how your ovaries will respond to fertility medication. Ivf in Iran is done.
- Semen analysis. If not done as part of your initial fertility evaluation, your doctor will conduct a semen analysis shortly before the start of an IVF treatment cycle.
- Infectious disease screening. You and your partner will both be screened for infectious diseases, including HIV. Ivf in Iran is done.
- Practice (mock) embryo transfer. Your doctor might conduct a mock embryo transfer to determine the depth of your uterine cavity and the technique most likely to successfully place the embryos into your uterus.
- Uterine cavity exam. Your doctor will examine your uterine cavity before you start IVF. This might involve a sonohysterography — in which fluid is injected through the cervix into your uterus — and an ultrasound to create images of your uterine cavity. Or it might include a hysteroscopy — in which a thin, flexible, lighted telescope (hysteroscope) is inserted through your vagina and cervix into your uterus. Ivf in Iran is done.
Before beginning a cycle of IVF, consider important questions.
About 12 days to two weeks after egg retrieval, your doctor will test a sample of your blood to detect whether you’re pregnant. Ivf in Iran is done.
- If you’re pregnant, your doctor will refer you to an obstetrician or other pregnancy specialist for prenatal care.
- If you’re not pregnant, you’ll stop taking progesterone and likely get your period within a week. If you don’t get your period or you have unusual bleeding, contact your doctor. If you’re interested in attempting another cycle of in vitro fertilization (IVF), your doctor might suggest steps you can take to improve your chances of getting pregnant through IVF.
The chances of giving birth to a healthy baby after using IVF depend on various factors, including:
- Maternal age. The younger you are, the more likely you are to get pregnant and give birth to a healthy baby using your own eggs during IVF. Women age 41 and older are often counseled to consider using donor eggs during IVF to increase the chances of success. Ivf in Iran is done.
- Embryo status. Transfer of embryos that are more developed is associated with higher pregnancy rates compared with less developed embryos (day two or three). However, not all embryos survive the development process. Talk with your doctor or other care provider about your specific situation. Ivf in Iran is done.
- Reproductive history. Women who’ve previously given birth are more likely to be able to get pregnant using IVF than are women who’ve never given birth. Success rates are lower for women who’ve previously used IVF multiple times but didn’t get pregnant.
- Cause of infertility. Having a normal supply of eggs increases your chances of being able to get pregnant using IVF. Women who have severe endometriosis are less likely to be able to get pregnant using IVF than are women who have unexplained infertility.
- Lifestyle factors. Women who smoke typically have fewer eggs retrieved during IVF and may miscarry more often. Smoking can lower a woman’s chance of success using IVF by 50 percent. Obesity can decrease your chances of getting pregnant and having a baby. Use of alcohol, recreational drugs, excessive caffeine and certain medications also can be harmful.
Talk with your doctor about any factors that apply to you and how they may affect your chances of a successful pregnancy. Ivf in Iran is done.